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integrin signaling pathway Transcription can also be impaire
2019-08-19
Transcription can also be impaired by lesions in the template DNA strand, which may lead to stalling of RNA polymerase (RNAP) or to transcriptional mutagenesis, thus producing mutant RNAs and proteins [[3], [4], [5], [6], [7]]. At the same time, RNAP can act as a sensor for DNA lesions, by attractin
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Compounds and possessed relatively low clogP
2019-08-19
Compounds 11–13 and 15 possessed relatively low clogP values and tended to show relatively weak antagonist activity regardless of their potent EP1 receptor affinity. Compounds 2–4, which were selected based on their potent in vivo antagonist activity, were found to be effective in an animal model.
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More unusual modifications also regulate DUBs Recent reports
2019-08-19
More unusual modifications also regulate DUBs. Recent reports have illustrated how reactive oxygen species (ROS) can regulate DUB activity 87, 88, 89, 90. ROS can serve as potent signaling molecules by reacting with active site cysteines of tyrosine phosphatases and some cysteine peptidases to form
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Given the fact that most criticism on
2019-08-19
Given the fact that most criticism on genetic association studies is the lack of replicability (Hirschhorn, Lohmueller, Byrne, & Hirschhorn, 2002), the aim of the present study is to investigate the influence of the DBH polymorphism rs1611115 (C-970T) on RD in two independent samples of healthy part
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br Acknowledgments Grant support was provided by the
2019-08-19
Acknowledgments Grant support was provided by the Leading Academic Discipline Projects of Shanghai Municipal Education Commission (J5028) (J50201) to Dr. Mi, the China National Science Foundation Project (81072076) to Dr. Mi, the China National Science Foundation Project (31000349) to Dr. Shen, a
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br Materials and methods br Results
2019-08-19
Materials and methods Results Discussion GOS potently inhibited SRD5A1 in COS-1 cells (Fig. 4A) and rat Leydig cells (Fig. 4B), possibly attenuating testosterone activation into DHT. It has been reported that gossypol inhibited human SRD5A1 with IC50 of 7 × 10−6 M [28]. Interestingly, gossy
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5104 manufacturer In vitro study indicated the
2019-08-19
In vitro study indicated the cell death of hippocampal neurons was mediated by DAPK1 following ceramide-3 treatment (Pelled et al., 2002). the same study showed that DAPK1-deficient mice treated by acyl ceramide exhibit a less sensitivity to apoptosis, this proposed that DAPK1 plays a central role i
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The first transcription factor TF known to interact with one
2019-08-19
The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone PNU-120596 of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed developmen
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N1-Methylguanosine-5\'-Triphosphate Acidic substituents
2019-08-19
Acidic substituents () showed moderate biochemical activity, but these compounds showed reduced cellular potency. Additional compounds bearing a carboxylic N1-Methylguanosine-5\'-Triphosphate were also prepared and tested (data not shown). All of acidic compounds showed low cellular potency regardl
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Cysteine protease inhibitors representing several
2019-08-17
Cysteine protease inhibitors representing several chemical scaffold types are effective in halting parasite replication without toxicity to the host (Renslo and McKerrow, 2006). A vinyl sulfone cysteine protease inhibitor, K11777, is completing final Good Laboratory Practice (GLP) preclinical tests
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We did not find any significant
2019-08-17
We did not find any significant associations between APOE genotype and BDI-II, BAI, or PAI clinical scale scores. Our results indicate that APOE is not likely to play a major role in psychiatric comorbidities in epilepsy. This is in line with studies in the general population, which have not found a
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In some of our studies we examined the occurrence of
2019-08-17
In some of our studies we examined the occurrence of ERβ and SHBG and a possible colocalization between them. Fig. 5 shows that there is no big difference in the occurence of ERβ after short time (A) as well as long time (B) treatment with E2. We can find the receptor at the cell membrane as well as
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These findings further extend our knowledge of how P
2019-08-17
These findings further extend our knowledge of how P4 and/or E2 can mediate anxiety and fear responses. Female rats in behavioral estrous and ovx rats administered systemic P4 and/or E2 demonstrated significantly less anxiety in the open field and/or elevated plus maze, compared to diestrous rats, a
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In principle in vitro techniques for assessing
2019-08-17
In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized T7 High Yield RNA formula lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with
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br Materials and methods br
2019-08-17
Materials and methods Results Discussion Plg plays important roles in various physiological processes, such as fibrinolysis, proteolysis, cell migration, differentiation, tissue remodeling, and inflammation [6], [7], [8]. We herein found that Plg deficiency enhanced insulin secretion, and w
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