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br Perspective and conclusion Collagen Toolkits
2020-04-29
Perspective and conclusion Collagen Toolkits II and III have been used to determine the ALW-II-41-27 for DDR1 and DDR2, and the main binding site is the GVM-GFO motif [103,108]. The co-crystal structure of the DS domain of human DDR2 bound to a synthetic collagen-like peptide containing the GVM-
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br Results br Discussion The process by
2020-04-29
Results Discussion The process by which MBCs differentiate from GC B cell precursors remains mostly uncharacterized, in large part because of the uncertainty surrounding the nature of the precursor selective estrogen receptor modulators within the GC. The identification here of a distinct sub
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Several eukaryotic E enzymes including
2020-04-29
Several eukaryotic E3 enzymes, including BRE1 [49], RNF8 [50], and RAD18 [24], [51], have been reported to partner with UBE2B in the ubiquitination of various targets. We examined the expression levels of these E3 enzymes in HONE1 and TW01 cells; RAD18 was highly expressed in these Syringin (data n
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UBA belongs to the non
2020-04-29
UBA5 belongs to the non-canonical E1 enzymes that lack a defined Cys domain but have the active-site Cys within the adenylation domain [24]. Similar to other E1 enzymes, UBA5\'s adenylation domain comprises an eight-stranded beta sheet that is surrounded by helices [21]. Moreover, like the ancestral
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GSK1838705A mg The first transcription factor TF known to in
2020-04-29
The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone GSK1838705A mg of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed develo
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In summary in the present
2020-04-29
In summary, in the present study we found that CysLT1 receptor attenuates while CysLT2 receptor facilitates OGD-induced PC12 cell death as confirmed by receptor over-expression and antagonism. However, we cannot explain why their roles are distinct and why the cell size is increased in the CysLT2 re
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The CysLT receptor antagonist BayCysLT RA significantly
2020-04-29
The CysLT2 receptor antagonist BayCysLT2RA significantly suppressed multiple antigen challenge-induced infiltration of eosinophils and mononuclear topirimate receptor into the lung, indicating that CysLT2 receptor activation is involved in leukocyte migration. In contrast to the present finding, Ba
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br Materials and methods br Results br Discussion
2020-04-29
Materials and methods Results Discussion Prolyl 4-hydroxylases are oxygenases with key roles in a variety of biological processes including oxygen sensing, siRNA regulation and collagen folding (Gorres and Raines, 2010). Hydroxyproline is particularly abundant in collagenous proteins which
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HA activates its receptor channels to
2020-04-29
HA activates its receptor channels to cause an inward chloride flux in the insect nervous system (Hardie, 1989). Two genes encoding the subunits of these channels were first identified in D. melanogaster: one previously known as ort (also differently named as hclA, DM-HisCl-α1, hisCl2 and Dm HA-Cl I
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br Results br Discussion CCA is a fatal tumor
2020-04-28
Results Discussion CCA is a fatal tumor originating from the intrahepatic bile duct and the prognosis is very poor (Hoyos et al., 2018). CCA is one of the most dangerous primary liver malignant tumors and the most common malignant tumor of the biliary tract worldwide. However, the underlying m
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br Conflict of interest br Acknowledgements The
2020-04-28
Conflict of interest Acknowledgements The authors are grateful to laboratory technician Kristina Andersson for expert technical assistance. The authors acknowledge the Swedish Research Council (Grant no. 6834), Region Skåne and Faculty of Medicine, Lund University, for financial support. In
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br Methods br Results br Discussion To
2020-04-28
Methods Results Discussion To our knowledge, this is the first report to investigate the association between DBH genotype and pDβH activity in Han Chinese subjects. We also examined the relationship among DBH gene polymorphisms, pDβH activity and cognitive function in patients with schizoph
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Third DGK protein stabilization by myristic acid is cell lin
2020-04-28
Third, DGKδ2 protein stabilization by myristic bmn 673 is cell line specific. Myristic acid had no obvious effects on DGKδ protein stability in the liver cell line HepG2, pancreas cell line MIA-PaCa-2 and neuronal cell line Neuro-2a cells (Fig. 5). Although myristic acid moderately increased the DG
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50014 br Inhibition of DHODH The final products a n
2020-04-28
Inhibition of DHODH The final products 7a–n were assessed for their DHODH inhibitory activity on rat liver mitochondrial/microsomal membranes. A procedure adapted from the literature was employed (see Experimental), in which oxidation of DHO to ORO is monitored by following the concomitant reduct
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Targeting both PARP and DHODH for anti cancer
2020-04-28
Targeting both PARP-1 and DHODH for anti-cancer therapy would certainly be beneficial as these enzymes share a common role in the DNA replication and repair mechanisms which are involved in the hyper-proliferation of cancer cells. Since benzimidazole-containing compounds have been reported to show g
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