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br Conclusions Enzyme prodrug therapy mediated by
2020-05-08
Conclusions Enzyme prodrug therapy mediated by implantable biomaterials combines the benefits offered by the site specific drug delivery techniques and the systemic administration of drugs. From the former, SMEPT inherits the localized mode of drug delivery with lower systemic distribution of the
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br Acknowledgments br Introduction Hypertensive retinopathy
2020-05-08
Acknowledgments Introduction Hypertensive retinopathy is a disease of the retinal microvasculature associated with elevated blood pressure (Fraser-Bell et al., 2017). Narrowing of retinal arterioles occurs in the early stage of the disease, and with persistent hypertension further vascular pat
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pkm2 br Funding br Disclosure of interest br Acknowledgments
2020-05-08
Funding Disclosure of interest Acknowledgments Introduction Pulmonary fibrosis (PF) is a chronic disease characterized by extensive deposits of the extracellular matrix (ECM) that can impair the architecture and function of the lungs (Cavazza et al., 2010). Imbalance between the prolifer
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Several studies have indicated that
2020-05-08
Several studies have indicated that ICT induces activation of ERK and p38 kinase in a variety of cells. The ERK pathway was involved in and partly contributed to the neuroprotective effects in rat neuronal Cap Firefly Luciferase mRNA [14] and anticancer effects in several cancer cells [5], [7], [8]
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Moreover maintaining the pyrimidine pool is not
2020-05-08
Moreover, maintaining the pyrimidine pool is not the only important role played by DHODHs. In Toxoplasma gondii, for instance, DHODH plays a second essential function [38] possibly coupled to the mitochondrial respiratory activity, where it replenishes ubiquinol levels and prevents reactive oxygen s
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br Conclusion Determining whether the multiple putative alga
2020-05-08
Conclusion Determining whether the multiple putative algal DGAT isoforms are functional DGATs via biochemical assays will be vital in our effort to genetically engineer algae to produce TAG on a large enough scale to make biodiesel production viable. As can be seen in O. tauri, it is possible tha
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br Materials and methods br Results The BUN
2020-05-08
Materials and methods Results The BUN and creatinine levels in the saline-treated CRF group were found to be significantly higher than those in the sham-operated control rats treated with either montelukast or saline (pTorcetrapib tissues, were found to be significantly higher in the saline-t
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This work aimed to investigate whether the increase in liver
2020-05-08
This work aimed to investigate whether the increase in liver lipid depots, observed in the fetuses from rats fed a saturated-fat-rich diet, persists later in life in the offspring (a) at 21days of age immediately after weaning and (b) at 140days of age, after healthy nourishing. Furthermore, we want
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br Experimental br Results and
2020-05-07
Experimental Results and discussion Fig. 2 shows schematically the fundamentals of the developed HRP-P4-(P4)-anti-P4-Protein-G-MBs/SPCE immunosensor. Oriented immobilization of anti-P4 was accomplished onto Protein G-MBs due to the Protein G binding ability with the Fc region of many mammals i
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GPR also known as EBI is a
2020-05-06
GPR183 (also known as EBI2) is a Gαi-coupled seven-transmembrane chemotactic receptor. It is highly expressed on follicular B cells, CD4+ dendritic cells (DCs), and CD4+ T cells but is downregulated on germinal center (GC) hinokitiol in secondary lymphoid organs and controls cell migration to achie
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br Discussion and conclusion Ubiquitination
2020-05-06
Discussion and conclusion Ubiquitination and deubiquitination have emerged as important mechanisms involved in p53 management. This review revealed that various DUBs can regulate p53 or p53-Mdm2-MdmX networks. Herein, we reviewed the current progress made toward elucidating the complexities in th
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In addition to G coupling it is important to consider
2020-05-06
In addition to Gα coupling, it is important to consider that the transition from goal-directed to habitual drug taking also relies on striatal D2R-A2AR heterodimers. Following cocaine self-administration, D2R-A2AR density is increased in the NAc, leading to greater antagonism of the inhibitory (ant
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N fowleri enters the host through the nasal cavity
2020-05-06
N. fowleri enters the host through the nasal cavity and travels via the olfactory nerve into the BML-277 where it causes PAM (Visvesvara and Stehr-Green, 1990). The ameba most commonly infects healthy young adults and children and is able to evade the immune system but also elicits extensive damagin
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(S)-AMPA br Results br Discussion GPCRs recognize
2020-05-06
Results Discussion GPCRs recognize a broad range of molecules with a vast chemical (S)-AMPA through different mechanisms. Our understanding of the recognition of lipid mediators by GPCRs primarily comes from the structural studies of receptors for lysophospholipids and endocannabinoids includ
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br Results br Discussion br Conclusions The present study de
2020-05-06
Results Discussion Conclusions The present study demonstrates that CRF1 receptor-deficiency prolongs whereas CRF2 receptor-deficiency shortens the duration of recognition memory deficits induced by morphine discontinuation, unraveling opposite roles for the two known CRF receptor subtypes i
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