Archives
- 2018-07
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
- 2024-06
- 2024-07
- 2024-08
- 2024-09
-
To determine whether serine phosphorylation could influence
2020-08-03
To determine whether serine 15 Enalapril Maleate australia could influence the ability of CK1 to phosphorylate p53, the GST-p53 fusion proteins (both murine and human) were phosphorylated stoichiometrically using recombinant DNA-PK and excess unlabelled ATP as phosphate donor. The proteins were boun
-
Cathepsin S inhibitor There are multiple E ligases
2020-08-03
There are multiple E3 ligases that can impact the pathobiology of atherosclerosis [38,39]. For example, HECT domain E3 ligases HUWE1 and NEDD4–1 control stability of the ATP-binding cassette transporter ABCG1 and ABCG4, both critical for cholesterol homeostasis [40]. In addition, the E3 ubiquitin li
-
DY131 Although the DPP enzyme is an amino dipeptidase with
2020-08-03
Although the DPP-4 enzyme is an amino-dipeptidase with relatively strict substrate requirements, preferring a proline or alanine residue in the penultimate position at the N-terminus, numerous other substrates of DPP-4 have been identified [56], [57]. Many of these are peptide hormones, the majority
-
br Experimental br Acknowledgements This research was financ
2020-08-03
Experimental Acknowledgements This research was financially supported by the Scientific and Technological Developing Scheme of Jilin Province of People\'s Republic of China (20150101225JC). Introduction Obesity is a serious health risk signal characterized by excess accumulation of triglyc
-
Complementing the localization studies experiments
2020-08-03
Complementing the localization studies, experiments with gene knockout mice and labelled substrates have provided further evidence of source-dependent preferential use of FA by the two DGAT isotypes. Liver-specific Dgat1 knockout mice are resistant to hepatic steatosis induced by high fat diet and p
-
torin australia MTHFR is one of the crucial enzymes involved
2020-07-31
MTHFR is one of the crucial enzymes involved in metabolism of homocysteine to methionine and hence defect in the activity of it could lead to a defective pathway of DNA methylation. In the current study, three polymorphisms i.e. rs2274976 (G1793A), rs1801133 (C677T) and rs1801131 (A1298C) have been
-
ILC regulation is also accomplished through competition for
2020-07-31
ILC regulation is also accomplished through competition for cytokine availability. ILC2 and ILC3 require IL-7 for development, while ILC1 and NK Anacardic acid sale mainly depend on IL-15 [1, 2, 3]. In an immunocompetent organism, the expansion of ILCs is limited by the presence of adaptive lymphoc
-
Imaging of primary Tfh cells at the peak of
2020-07-31
Imaging of primary Tfh cells at the peak of the GC response revealed clear spatial segregation in the FM and GC compartments. This confinement was confirmed by TPP and discontinuous cell tracking 24 hr later, which showed retention of the majority of photoconverted GC Tfh cells in the original GC an
-
In the current study cocaine
2020-07-31
In the current study, cocaine did not significantly increase negative subjective effects and nepicastat did not increase these responses. This outcome is somewhat surprising given that the most commonly reported effect to date has been to increase the aversive properties of cocaine such as anxiety,
-
BMS 777607 We describe a year old
2020-07-31
We describe a 37-year-old man with a family history positive for HNPP due to a BMS 777607 of the PMP22 gene (father). The patient (hereafter named proband) complained of fatigue, light-headedness, bilateral blurred vision and increased perspiration arising on assuming or maintaining the upright pos
-
Using polyclonal antibodies against the E
2020-07-31
Using polyclonal GSK2578215A receptor against the E. coli Ada protein, two groups of microorganisms have been identified according to prevalence of the Ada response. Although the eukaryotic fungus A. nidulans lacked the response, it has preserved adaptability to alkylating agents. In some species,
-
Recently Schenck et al identified an active site
2020-07-31
Recently, Schenck et al. [25] identified an active site asparagine 222 (N222) residue in the Glycine max TyrAp/PDH (GmPDH1) that is responsible for its prephenate substrate specificity. Mutating the single N222 into an acidic residue (i.e. aspartate, D) in the legume TyrAp/PDH shifted from prephenat
-
Cy7 carboxylic acid (non-sulfonated) Research using animal m
2020-07-31
Research using animal models has indicated a critical role for the interaction between dopaminergic activity in the prefrontal cortex and striatum in set-shifting. Specifically, cognitive flexibility is impaired by a combination of decreased prefrontal dopamine (DA) and elevated striatal DA, while c
-
Cannabis use is exceedingly common Bahorik et al and
2020-07-31
Cannabis use is exceedingly common ((Bahorik et al., 2014) 8%) and overwhelming evidence suggests that, especially during adolescence, it represents a major risk factor for psychosis (Gage et al., 2016), associated with earlier onset and more pronounced symptoms (Arseneault et al., 2002, 2004). More
-
Structural comparison of PcP H with PPHD
2020-07-31
Structural comparison of PcP4H1 with PPHD and human HIF1α-PHD2 reveals that DSBH core fold, Fe2+ and 2-oxoglutarate Cy5 amine (non-sulfonated) are all conserved. The low affinity of PcP4H1 for 2-oxyglutarate (550 mM) relative to the K value of 2-oxoglutarate for PPHD (400 μM) [13] suggests that othe
14401 records 715/961 page Previous Next First page 上5页 711712713714715 下5页 Last page