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We analyzed whether HaCaT cells treated
2021-02-24
We analyzed whether HaCaT ML 141 treated with PLD can alter the expression of genes involved in DNA damage response. Key DNA damage cues activate the sensory DNA-PK/ATM/ATR kinases, which relay two parallel cascades that ultimately serve to inactivate the Cyclin B-cdc2 complex. The protein kinases
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Spinal cord injury leads to an extensive inflammatory cascad
2021-02-24
Spinal cord injury leads to an extensive inflammatory cascade on spinal cord and the release of pro-inflammatory cytokines can sensitize neurons, activating signaling pathways that will result in thermal and mechanical hypersensitivity [39]. In this regard, Guo and collaborators (2014) demonstrated
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Although in vitro and in vivo
2021-02-24
Although, in vitro and in vivo immunosuppressive effects of female steroids have been described in fish (Yamaguchi et al., 2001, Law et al., 2001), their mode of action was not evaluated in detail. Consequently, it is of considerable interest to investigate the intracellular pathways that regulate t
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In our xenograft study Fig
2021-02-24
In our xenograft study (Fig. 7, Fig. 8), we observed that DYD acts very similarly to progesterone; the initial faster tumor growth in the PGRMC1-transfected MCF7 tumor was not significant compared with that with progesterone, in TNP-470 to the greater tumor growth observed with norethisterone. This
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We hypothesize that both IGF dependent kinase activation
2021-02-24
We hypothesize that both IGF-1-dependent kinase activation and locally synthesized neuroestrogens interactively regulate estrogen receptor activity in neuronal 2,4-Diacetylphloroglucinol in the absence of exogenously applied estradiol. The Neuro-2A cell line was chosen as the model system for these
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Bioinformatics analysis for genes encoding proteins ESR IL
2021-02-24
Bioinformatics analysis for genes encoding proteins (ESR1, IL6, TERT, DNMT3B) showed that NF-kB is one of the transcription factors that might be regulating their expression, especially for IL6, TERT and DNMT3B genes. Previous studies have demonstrated that PA induces NF-kB activation, thus increasi
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With regards to translational development of
2021-02-24
With regards to translational development of SMEPT, we acknowledge that we are not aware of any trials currently underway to validate this methodology in clinical settings. It appears fair to say that enthusiasm and commitment from corporate developers does not match that of academic partners. One r
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Phosphatase Inhibitor Cocktail 2 (100X in ddH2O) Another cri
2021-02-24
Another critical finding in this study is that the level of αSyn oligomers in the SN of σ1R−/− mice was progressively increased with age, whereas the levels of αSyn monomers and αSyn messenger RNA (data not shown) were not altered compared to WT mice. A number of studies reported that soluble αSyn m
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In pregnancy maternal uterine spiral artery SA remodeling is
2021-02-24
In pregnancy, maternal uterine spiral artery (SA) remodeling is essential for ensuring efficient blood flow to the developing fetus. A subset of CD49a+Eomes+ decidual NK Tubastatin A (dNK) that actively secretes GFs, such as pleiotrophin and osteoglycin, have recently been described in humans and in
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How does an increase in E affinity
2021-02-24
How does an increase in E2 affinity for the RING domain favor higher activity and polyubiquitination by the E2? Binding of the RING domain to the E2 positions the donor Ub in the E2~Ub conjugate in a closed complex [16], [17], [18] that increases the reactivity of the thioester [60]. A higher affini
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Necrostatin 1 Since the interaction between the E and E is w
2021-02-24
Since the interaction between the E2 and E3 is weak and transient, it has been difficult to identify novel interactions between specific E2/E3 complexes [59], [64]. Here we used a modified bait consisting of the Mulan RING domain fused to one of the four E2s isolated in our screen and expressed in y
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There are a few visible
2021-02-24
There are a few visible DNA staining methods, which use dyes such as methylene blue, brilliant cresyl blue [7], crystal violet [8], Nile blue [9], [10] and ethyl violet [11]. However, although safe, these methods require long staining times, lack sensitivity and are not specific for nucleic acids.
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Many DNA repair pathways are candidates for DPC repair
2021-02-24
Many DNA repair pathways are candidates for DPC repair. Nucleotide excision repair (NER) is widely involved in both bacteria and eukaryotes in removing cross-linked protein with low molecular weights (11kDa) (Ide et al., 2011). The predominant pathway chosen by SR 11302 may also depend on the type o
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br Material and methods br Results br
2021-02-23
Material and methods Results Discussion In the present study, twenty strains of Y. enterocolitica were analyzed for their inhibitory potential on cysteine proteases. Five of these strains belonged to bioserotype 4/O:3, which is distinguished for its pathogenicity towards humans. The rest of
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Several evidences showed that seizures increase brain
2021-02-23
Several evidences showed that seizures increase brain extracellular glutamate, which binds to N-methyl-d-aspartate (NMDA) receptor, then up-regulated cyclooxygenase-2 (COX-2) expression in brain capillaries to increase BBB P-gp expression [11,13,29,30]. A recent study demonstrated a different signal
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