Archives
- 2018-07
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
- 2024-06
- 2024-07
- 2024-08
- 2024-09
-
br Materials and Methods br Acknowledgements br
2021-03-04
Materials and Methods Acknowledgements Introduction The discoidin domain receptors, DDR1 and DDR2, are two closely related receptor tyrosine kinases (RTKs) that contain a discoidin (DS) homology domain in their extracellular regions. The DDRs were initially discovered by homology cloning ba
-
Phorbol 12,13-dibutyrate receptor br Conclusions and future
2021-03-04
Conclusions and future directions In recent years we saw major advances in our knowledge of H2A-DUB biology, with discovery of novel mammalian H2A-DUBs, better understanding of their biochemical properties, and development of several animal models to address their in vivo functions. However at pr
-
br Introduction Coping with DNA damage is possible
2021-03-04
Introduction Coping with DNA damage is possible thanks to surveillance mechanisms (checkpoints), that detect the problem and promote its solution [1], [2], and to repair and tolerance pathways that remove the lesions or reduce the damage consequences [3], [4]. Failures in these processes have a h
-
br Introduction Sphingolipids are ubiquitous membrane compon
2021-03-04
Introduction Sphingolipids are ubiquitous membrane components of all eukaryotic cells belonging to a group of complex lipids. The basic structure of sphingolipids is composed of a sphingoid long chain base (LCB) linked to a fatty indy 6 via an amide bond to form a ceramide [1]. In animals, sphing
-
Although the phase I clinical trial of LMB was unsuccessful
2021-03-03
Although the phase I clinical trial of LMB was unsuccessful, the detailed review of this trial only mentions some malaise and anorexia as side effects, which are common for most effective chemotherapeutic drugs. These side effects may diminish if lower doses are administered. In view of the novel CR
-
br Results and discussion br Conclusion In
2021-03-03
Results and discussion Conclusion In this research, several anti-inflammatory agents with pyrazolo[3,4-d]pyrimidine cores were synthesized. Such choice of large core than regular pyrazole was valid as a proper modification. That most of the prepared compounds showed excellent AI activity. In a
-
Interestingly selective ETA blockade increased
2021-03-03
Interestingly, selective ETA blockade increased cutaneous blood flow as measured by laser Doppler fluxmetry. This is a measure of total blood flow in the different vessels in the skin including venules, carboxypeptidase a as well as arterioles. This finding is in accordance with the previous demons
-
In brief while previous studies have evaluated the
2021-03-03
In brief, while previous studies have evaluated the individual roles of VDR and ER signaling pathways in breast cancer, in the present study we performed an in silico approach for comparative evaluation of these pathways. Considering the complex interaction networks in the context of cancer, such co
-
In conclusion BmSpry was targeted
2021-03-03
In conclusion, BmSpry was targeted by three viruses to regulate the ERK pathway and thus ensure viral reproduction in the silkworm. This is the first report regarding a general mechanism of host regulation by multiple silkworm viruses, and this can pave the way for future virus control in other inse
-
The present study also showed that EP deficiency
2021-03-03
The present study also showed that EP2 deficiency and EP4 antagonism significantly suppressed psoriatic Imiquimod in an imiquimod model. Notably, however, the combined EP2 deficiency and EP4 antagonism did not completely suppress ear swelling in this model, possibly because there is the IL-17–indep
-
Yu et al also reported that extracting
2021-03-03
Yu et al. [24] also reported that extracting consortium of hydrolytic enzymes from sludge flocs performs better than costly single purified commercial enzyme. Thus, it is concluded from the above cited literature analysis that only few studies have been reported on extraction of enzymes from waste s
-
br Results and discussion br Conclusion Recent
2021-03-03
Results and discussion Conclusion Recent studies showed that EGFR signaling is involved in inflammatory response in several inflammatory conditions. The normal inflammatory macrophage Rapalink-1 show EGFR-dependent production of inflammatory mediators. Nevertheless, the development of EGFR inh
-
cGAS has a central role in STING
2021-03-03
cGAS has a central role in STING activation after DNA sensing, but it is unknown if most of the DNA sensors act independently or in cooperation with the cGAS-cGAMP pathway. This was addressed for IFI16 (Almine et al., 2017, Jønsson et al., 2017) and PQBP1 (Yoh et al., 2015) but remains to be tested
-
br Acknowledgement br Introduction Human dihydroorotate dehy
2021-03-03
Acknowledgement Introduction Human dihydroorotate dehydrogenase (hDHODH), a flavin-dependent mitochondrial enzyme involved in de novo 85 8 biosynthesis, is a validated therapeutic target for the treatment of autoimmune diseases such as rheumatoid arthritis and cancer [1], [2], [3]. Leflunomid
-
Intriguingly our laboratory has shown that the
2021-03-03
Intriguingly, our laboratory has shown that the I638F kinase domain mutant, unlike the L63V and G505 mutants, is incapable of receptor autophosphorylation and activation of its downstream effector SHP-2 when exposed to collagen stimulation. These data indicate that I638F is a loss of function mutati
14415 records 605/961 page Previous Next First page 上5页 601602603604605 下5页 Last page