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Curcumin is a polyphenol extracted from turmeric which
2021-03-22
Curcumin is a polyphenol extracted from turmeric, which is commonly used as a spice and food-coloring agent in many cultures [9]. Curcumin possesses anti-inflammatory, antioxidant, and cancer-preventive properties [10], [11], [12]. In addition to these well-known effects, consuming curcumin may bene
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In summary A is a potent orally
2021-03-22
In summary, A-216546 is a potent, orally available endothelin receptor antagonist with a high selectivity for the endothelin ETA receptor. The potency and bioavailability of A-216546 suggest that it will have important utility for preclinical evaluation of the pathophysiology of the endothelin syste
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Studies using SERPINB deficient mice
2021-03-22
Studies using SERPINB1-deficient mice established the significant role for SERPINB1 in protecting lung antimicrobial proteins from proteolysis during microbe infection and its regulatory role in sustaining the balance of neutrophil reserve [15]. Neutrophil serine proteases (NSPs) (elastase, cathepsi
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In some cases more than
2021-03-22
In some cases, more than one CYP450 enzyme may be involved in the metabolism of a drug, and an Eadie–Hofstee plot is usually more reliable for assessing the involvement of multiple CORM-3 (Bu, 2006). Therefore, we first plotted the Eadie–Hofstee curves and observed their shape to determine the kine
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aminoisobutyric acid BAIBA is a
2021-03-22
β-aminoisobutyric Labetalol HCl (BAIBA) is a natural catabolite of the branched-chain amino acid thymine. BAIBA was recently found to reduce inflammation in skeletal muscle via the AMP-activated protein kinase (AMPK)-peroxisome proliferator-activated receptor (PPAR)δ signaling pathway. BAIBA report
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br Molecular modeling study Molecular modeling study was
2021-03-22
Molecular modeling study Molecular modeling study was essentially needed to understand and interpret the DHFR inhibitory pattern of this new class of compounds. Computational docking is an algorithm designed to estimate two main terms. The first is to determine the suitable position and the orien
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Preparation of the regioisomeric pyridooxazepinones
2021-03-22
Preparation of the regioisomeric pyridooxazepinones 10 and 11 was accomplished utilizing the synthetic sequence depicted in Scheme 3. Amide coupling of 63 and Emodepside chloride 64 afforded amide 65. Removal of the alcohol protecting group, followed by base catalyzed cyclization afforded a 1:2.4 mi
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Since free testosterone diffuses into a target organ a
2021-03-22
Since free testosterone diffuses into a target organ [1], a remarkable increase in free testosterone in plasma is expected to enhance androgen response in target organs including the prostate. In fact, the results of the present study showed testosterone and DHT levels, and mRNA expression levels of
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Lithocholic Acid sale Models and theories The CPA
2021-03-22
Models and theories The CPA equation of state is composed predominantly of two parts: physical item and the association item based on the thermodynamic perturbation theory [21], [22], [26], [27]. The physical item is used to represent intermolecular physical interaction, usually representing the SR
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The dermal ECM also shows specificities
2021-03-22
The dermal ECM also shows specificities. During zebrafish embryogenesis, the epidermis is composed of the outer periderm and the inner basal keratinocytes, which are responsible for the initial deposition of ECM in the primitive acellular dermis [17].The dermal endothelial cells, a species-specific
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br Progestogens and autoimmune diseases br Conclusion
2021-03-22
Progestogens and autoimmune diseases Conclusion Take-home messages Introduction The benefits of breastfeeding for both women and their infants are considerable [1], [2], [3]. The World Health Organization (WHO) recommends infants breastfeed exclusively during the first months of life [4]
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br Membrane receptor Indirect non
2021-03-22
Membrane receptor: Indirect non-genomic signaling As mentioned above, not all biotin-LC-LC-tyramide synthesis responses fit the classical genomic model of steroid action. The observation of excessively fast estrogen-induced biological responses led to the development of the hypothesis that estro
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The mechanism by which OC
2021-03-22
The mechanism by which OC use leads to impaired glucose tolerance is yet to be fully clarified. Decreased insulin sensitivity appears to be mainly accounted for by estrogenic component and this effect may be modified by progestogenic component [14], [15]. Estrogenic effect on glucose tolerance has b
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br Materials and methods br Results
2021-03-22
Materials and methods Results and discussion Conclusions In the present study, we have shown the important role of miR-204-5p in C2C12 myoblast differentiation. Overexpression of miR-204-5p inhibited myogenic differentiation and decreased the formation of slow-twitch myofibers, whereas miR-
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The genes corresponding to TVAG TVAG TVAG TVAG and
2021-03-19
The genes corresponding to TVAG_263740, TVAG_487600, TVAG_282090, TVAG_170370, and TVAG_148010 seem to be the less expressed, and undetectable by proteomics approach. In comparison, in other T. vaginalis strains, and experimental conditions, they show very few or null EST's reports [4]. Concludin
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