• There are also data showing potential

  2021-09-07

  

  There are also data showing potential beneficial effects of SGLT2i on non-alcoholic fatty liver disease (NAFLD) [[14], [15], [16], [17]], a hepatic manifestation of the metabolic syndrome that has been linked to type 2 diabetes mellitus (T2DM) development and increased cardiovascular (CV) as well as

• Previously we have shown that ghrelin and cannabinoids stimu

  2021-09-07

  

  Previously, we have shown that ghrelin and cannabinoids stimulate hypothalamic AMPK activity (Kola et al., 2005). In contrast, both the orexigenic compounds have inhibitory effects on AMPK activity in the liver and visceral fat (Kola et al., 2005). In this study, we were able to reproduce our previo

• br Introduction GPR also known as free fatty acid receptor

  2021-09-06

  

  Introduction GPR40 (also known as free fatty Bilirubin receptor 1), a member of the G-protein coupled receptor (GPCR) family, is expressed in pancreatic beta cells, intestine and the central nervous system (Bekinschtein et al., 2008; Itoh et al., 2003). It is activated by medium- and long-chain

• The canonical tumor suppressor p has also been

  2021-09-06

  

  The canonical tumor suppressor p53 has also been implicated as a transcriptional mediator of ferroptotic death (Jiang et al., 2015, Tarangelo et al., 2018, Wang et al., 2016, Xie et al., 2017). Specifically, p53 negatively regulates transcription of SLC7A11, the cystine-glutamate antiporter (Xc-) (J

• doxercalciferol During the activation of the coagulation cas

  2021-09-06

  

  During the activation of the coagulation cascade, factor Xa (FXa) forms a complex with activated factor V and calcium doxercalciferol on the surface of platelet membrane (so called prothrombinase complex) and converts prothrombin to thrombin [5], [6]. Selective FXa inhibitors do not directly inhibi

• br Acknowledgement The authors would like to thank

  2021-09-06

  

  Acknowledgement The authors would like to thank the University of Johannesburg and the National Research Foundation for the financial support. Mr. D Harris and Dr. R Meyer from Shimadzu South Africa are thanked for their technical support. Prof Ian Dubery is thanked for access to the LC-MS instr

• Here we dissect X chromosome dosage compensation DC in

  2021-09-06

  

  Here, we dissect X chromosome dosage compensation (DC) in C. elegans to determine the effect of chromatin modifications on higher-order chromosome structure during long-range gene regulation. DC is exemplary because it controls hundreds of genes simultaneously, it distinguishes X chromosomes from au

• HDAC enzymes oppose the effects of HATs by reversing lysine

  2021-09-06

  

  HDAC enzymes oppose the effects of HATs by reversing lysine acetylation, an action that restores the positive charge of the lysine thus stabilizing the local chromatin structure. By removing acetyl groups from ε-amino lysines of proteins, HDACs not only alter transcription, but also promote either t

• br Patients and methods br Results br Discussion The positiv

  2021-09-06

  

  Patients and methods Results Discussion The positivity of serum anti-HBc is the most commonly used marker to confirm the history of HBV infection. Quantification of serum anti-HBc has been explored as a marker of HBV-induced hepatitis and the adaptive immune response against HBV infection a

• HBV VL quantitation has been shown

  2021-09-06

  

  HBV VL quantitation has been shown to be affected by genotype/subtype, and varying degrees of positive and negative bias has been seen in previous comparison studies when analyzing across HBV genotypes. In studies comparing RealTime and Cobas for example, negative bias of ∼0.25 log10 was seen for ge

• br Discussion CHO K cell lines

  2021-09-06

  

  Discussion CHO-K1 cell lines stably expressing each of the NH2-terminal isoforms of the human glycine reuptake transporter GlyT1 have been developed. GlyT1 uptake assays have been validated for two lines for each isoform, one low and high expressor. Expression levels in the lines have been confir

• Elimination of the Q R bridge significantly

  2021-09-06

  

  Elimination of the Q234–R244 bridge significantly affected the protein NHS-12-Biotin but had little effect on its activity at a permissive temperature, which may seem contrary to the known functional importance of this motif in Fpg. However, since the mutants fully or partially retained the bound z

• As our earlier study investigated glut mRNA levels in respon

  2021-09-03

  

  As our earlier study investigated glut mRNA levels in response to a protein load contained in a meal and the studies that used glucose and insulin injections did not examine GLUT expression, this study sought to investigate the effects of hyperglycaemia and insulin on mRNA levels in the spiny dogfis

• br Materials and methods br Results br

  2021-09-03

  

  Materials and methods Results Discussion Common to catfish fry production, high stocking densities as well as intensive handling during transport can result in low dissolved oxygen levels (Abdalla and Romaire, 1996; Torrans et al., 2003), which can result in fish stress. It is not known at

• Acknowledgments br Introduction The gut derived hormone oxyn

  2021-09-03

  

  Acknowledgments Introduction The gut-derived hormone oxyntomodulin (OXM) is a naturally occurring dual agonist of both the glucagon receptor (GCGr) and glucagons-like peptide 1 receptor (GLP-1r). Structurally OXM is the 29 AZ505 ditrifluoroacetate mg of glucagon with a C-terminal octapeptide ta

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