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Given the proposed importance of conformational
2022-03-08
Given the proposed importance of conformational dynamics to GCK's allosteric regulation, a number of biophysical methods have been utilized to probe the enzyme's dynamic structural landscape. Investigations into the mechanism of Sulfo-NHS-LC-Biotin binding, using changes in the enzyme's intrinsic f
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Since the late s synthetic GC e g prednisone
2022-03-08
Since the late 1940s, synthetic GC (e.g. prednisone, prednisolone, dexamethasone) have been used extensively in the treatment of chronic inflammatory conditions such as rheumatoid arthritis and asthma, and for their immunosuppressant action in preventing organ rejection post transplantation. Cortico
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Medulloblastoma predominantly occurs in infants and children
2022-03-08
Medulloblastoma predominantly occurs in infants and children, and is the most-common type of paediatric malignant TOK-001 receptor tumour, accounting for about 20% of all childhood brain tumors [63]. According to cancer genomics, medulloblastoma consists of at least 4 distinct subgroups: Hh driven,
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Atractyloside Dipotassium Salt Knowing that our strongest ph
2022-03-08
Knowing that our strongest phenotypic differences between the genotypes involved feeding behavior in various contexts, we decided to examine the case of restricted feeding and food anticipatory activity. Animals faced with a restricted schedule of food availability develop a series of anticipatory b
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Determination of enzyme activity differs from other analytic
2022-03-07
Determination of enzyme activity differs from other analytical procedures. In this good intentions case, instead of enzyme concentration, a substrate depletion or product accumulation should be monitored. Such approach allows calculating activity basis of calibration curves performed for enzymatic
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Bile acids BAs are critical for facilitating
2022-03-07
Bile acids (BAs) are critical for facilitating the Human Angiopoietin 4 / ANG4 / ANGPT4 Protein (His Tag) of dietary lipids and lipid-soluble vitamins in the intestines [6], [7]. At physiological levels, BAs function as signaling molecules and activate specific nuclear receptors [farnesoid X recep
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br Introduction In addition to glucose which is the foremost
2022-03-07
Introduction In addition to glucose, which is the foremost stimulator of insulin secretion in beta-cells, other nutrients such as free fatty acids (also called non-esterified fatty acids, NEFA) contribute to glucose-stimulated insulin secretion (GSIS). Glucose triggers the processes leading to in
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BRD 7389 Defining the cooperation between molecular pathways
2022-03-07
Defining the cooperation between molecular pathways within highly complex biological systems, such as those between immune cell networks and target tissues is certainly a hard task. Recently, there are many investigations in the pathogenesis of renal graft rejection, one of the most evident investig
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To date the crystal structures
2022-03-07
To date, the crystal structures of HIV-1 IN complexed with ligands and related proteins could help us in studying the interactions between the inhibitors and IN. Until now, 114 co-crystal structures of HIV-1 IN with small molecular ligands 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34,
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Introduction The Antiretroviral Therapy ART
2022-03-07
Introduction The Antiretroviral Therapy (ART), in the last decade, has been providing a better treatment for the Human Immunodeficiency Virus 1 (HIV) infection, by reducing its viral load to undetectable levels and recovering the immune system. In fact, according to the last data from UNAIDS the mo
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Another important outcome of reducing hypothalamic
2022-03-07
Another important outcome of reducing hypothalamic HIF in DIO was the increase in gliosis and hypothalamic inflammation. Both experimental and human studies have shown that hypothalamic inflammation plays an important role in obesity by inducing resistance to anorexigenic signals, such as insulin an
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br Conclusion The mitochondrial and glycolytic energy metabo
2022-03-07
Conclusion The mitochondrial and glycolytic energy metabolism of the brain is coordinated by HKI binding to MOM, although the molecular mechanism of such a regulation is not yet clear. The protein kinase for HKI in MOM are VDACs [[5], [6], [7]], mainly the VDAC1 isoform [8]. Using a computational
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In our study we found
2022-03-07
In our study, we found that HER2-mutant lung cancers occurred commonly in female patients with an advanced stage at time of diagnosis and in a relatively younger age group. Previously, Mazières et al. [8] obtained comparable epidemiological findings, including a median age of 60 years, a high propor
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Ciprofloxacin hydrochloride Several bacterial functional pat
2022-03-07
Several bacterial functional pathways were observed after DON administration, of which signal transduction, metabolism and genetic information processing displayed the highest levels of enrichment. Importantly, these three pathways were reported to be closely associated with DON's toxicity. Many evi
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Transcriptional elongation is a checkpoint for productive tr
2022-03-07
Transcriptional elongation is a checkpoint for productive transcription. In ESCs, ∼50% of the genes enriched for H3K4me3 are initially transcribed but do not enter productive elongation (Guenther et al., 2007, Rahl et al., 2010). Following promoter escape, the transcriptional elongating protein comp
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