• Pharmacological inhibition of PKR seems

  2022-08-13

  

  Pharmacological inhibition of PKR seems to be an interesting strategy for revealing the role of PKR in oxytosis and ferroptosis. The oxindole/imidazole derivative C16 was identified by screening a library of 26 different ATP-binding site-directed inhibitors of varying structure that is more selectiv

• Introduction Type diabetes T D

  2022-08-13

  

  Introduction Type 2 diabetes (T2D) has been seriously affecting the health life of 415 million people and 193 million undiagnosed people [1]. Importantly, this disease was found to cause death at least 1.5 million annually, and has brought about an extensive health concern throughout the world [2,3

• n acetylneuraminic acid sale While more detailed molecular s

  2022-08-13

  

  While more-detailed molecular studies on the mechanistic basis for heightened H3 receptor function in PAE rats are underway, we have also been exploring whether PAE alters other markers of histaminergic neurotransmission in affected brain regions. One question is whether PAE affected the number of h

• There have been a few studies investigating the effects

  2022-08-13

  

  There have been a few studies investigating the effects of histamine on mast cells but the majority of these has been on rodent and cultured mast cells (Hofstra et al., 2003, Lippert et al., 2004, Jemima et al., 2014). How representative these systems are of primary human cells is a moot point since

• The electroconductive or electrocatalytic properties of cond

  2022-08-13

  

  The electroconductive or electrocatalytic properties of conductive moieties including polymers in combination with carbon or metal-based nanomaterials have also been explored. For example, Dong et al. (2017) developed a portable electrochemical immunosensor by creating a film of Prussian blue chitos

• In this study we present the first data on

  2022-08-13

  

  In this study, we present the first data on the kinetic properties of the hexokinase of T. equiperdum, which we compare with similar data available for pleomorphic T. brucei (Seed and Baquero, 1965, Nwagwu and Opperdoes, 1982, Hara et al., 1997, Morris et al., 2006, Chambers et al., 2008b, Chambers

• br Acknowledgements br Introduction The glutathione S transf

  2022-08-12

  

  Acknowledgements Introduction The glutathione S-transferase (GST, EC 2.5.1.18) family of multifunctional enzymes plays a particularly important role in cellular detoxification [1]. Over-expression of the GSTP1 isoform characterizes many human tumor cell lines derived from stomach, brain and co

• br Introduction Activation of the lipid sensing receptor GPR

  2022-08-12

  

  Introduction Activation of the lipid sensing receptor, GPR55, by lysophosphatidyl inositol (LPI) has been well documented, and implicated in endocannabinoid signaling [1]. Intracellular events resulting from GPR55 activation include; enhanced β-arrestin activity, calcium mobilization and ERK1/2 p

• The current study also inferred that MT content

  2022-08-12

  

  The current study also inferred that MT content in Crassostrea gigas might be associated with the Cd level, and can be affected by MT turnover. The Agarose GPG/LMP low melt of MT in cytosol is beneficial for aquatic organisms to adapt the seawater contaminated by heavy metals, and MT is a biomarker

• br Membrane transporters as a novel

  2022-08-12

  

  Membrane transporters as a novel therapeutic target in pediatric TBI The concept of targeting membrane transporters began with identifying a neuroprotective drug and a corresponding transporter inhibitor. Somewhat serendipitously, we discovered that N-acetylcysteine (NAC), a cysteine donor for GS

• br Materials and methods br

  2022-08-12

  

  Materials and methods Results Discussion l-glutamate is the major excitatory neurotransmitter in the brain, and is functionally involved in many processes of the nervous system which have been connected with several neurological diseases [4]. These conditions are characterized by the time-d

• tie2 br Characterization and regional localization of

  2022-08-12

  

  Characterization and regional localization of Glu transporters Molecular studies led to the description of five subtypes of plasma membrane Glu transporters termed in accordance to their human or rodent origin (Kanai and Hediger, 1992, Pines et al., 1992, Storck et al., 1992). In humans, these tr

• Through the analysis of various

  2022-08-12

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic LDN193189 Hydrochloride motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of

• br Regulation of Glu transporters The

  2022-08-12

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino Nogo-66 (1-40) calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include trans

• The discovery that GLUT in the microvasculature represents a

  2022-08-12

  

  The discovery that GLUT1 in the microvasculature represents an important target of VEGF thereby affecting tachykinin receptor function is highly relevant. The work of Jais et al. identified VEGF as a determining player in the regulation of cognitive performance and provides an important link to the

15521 records 372/1035 page Previous Next First page 上5页 371372373374375 下5页 Last page