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In this study in an effort to explore the
2023-03-01
In this study, in an effort to explore the possible role of 5-HT6 receptors in mediating the memory-enhancing effects of YL-0919, we first assessed the memory-enhancing effects of YL-0919 in the Morris water maze, object recognition test and step-down passive avoidance task. In addition, we then inv
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GMF was later localized to
2023-03-01
GMFβ was later localized to the cytosol of primary astrocytes and glioma cell lines [67], prompting investigations into its involvement in intracellular signaling. It was found that PKA phosphorylation of GMFβ inhibits the ERK1/2 branch of the MAP kinase pathway [73], yet activates the stress-respon
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br Antioxidative stress and anti inflammation Oxidative stre
2023-03-01
Antioxidative stress and anti-inflammation Oxidative stress is a major cause of reduced endothelial NO bioavailability in hypertension, and inflammatory response is thought to play an important role in these processes (Blake and Ridker, 2001, Landmesser et al., 2006). Reactive oxygen species (ROS
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Introduction hydroxytryptamine HT is found
2023-03-01
Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary Trovafloxacin mesylate synthesis (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008).
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The role of DHT in early teleost embryogenesis is not
2023-03-01
The role of DHT in early teleost embryogenesis is not entirely clear or established, however additional studies that treat fish embryos to DHT or to specific srd5a inhibitors at critical stages of development (i.e. prior to sex differentiation) will shed light on the early functions of this androgen
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Cancer cells manifest characteristic abnormal growth propert
2023-03-01
Cancer caffeic acid manifest characteristic abnormal growth properties accompanying clonal evolution of cells displaying progressively increasing genomic instability capable of invasion and metastasis to distant organ sites. With the emerging knowledge about the role of known oncogene and tumor supp
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Using this cheese mimicking matrix we screened the antifunga
2023-02-25
Using this cheese-mimicking matrix, we screened the antifungal activity of 44 LAB fermented milk-based products and 23 LAB isolates used as protective cultures against 4 fungal targets. The LAB were obtained from the culture collections of CIRM-BIA (Centre International de Ressources Microbienne-Bac
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Animal fat appears to increase C perfringens counts
2023-02-25
Animal fat appears to increase C. perfringens counts compared with vegetable oil, so there may indeed be some advantage to vegetable diets at least in terms of fat sources (Knarreborg et al., 2002). Small grains such as wheat, rye, oats, and barley, with high levels of non-starch polysaccharides are
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br Experimental procedures br Results br
2023-02-25
Experimental procedures Results Discussion Our biophysical and cellular analyses of mutant Aβ1–42 peptides support a role of the N-terminus of Aβ in peptide aggregation and toxicity. We demonstrate that double mutations constructed to humanize the rodent Aβ1–42 sequence result in a signific
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br Discussion The patient presented initially only
2023-02-25
Discussion The patient presented initially only with parietal symptoms in the form of acalculia, visuo-spatial deficits, and visuo-perceptual deficits and dressing apraxia. He also had simultognosia as early symptoms. Later when the disease progressed he had recent memory deficits and language in
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br Conflicts of interest br Acknowledgements This work was
2023-02-25
Conflicts of interest Acknowledgements This work was sponsored by grants from Longyan University Scientific Research Fund for the Young Scholars (LQ2016010), Middle-aged and Young Teachers Education Research Projects of Fujian Province (JAT170569), Longyan University Scientific Research Fund f
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br Conclusions Several lines of evidence have been
2023-02-25
Conclusions Several lines of evidence have been established, which support the adenosine kinase hypothesis of epileptogenesis, which is based on a sequence of events leading from acute WAY 208466 dihydrochloride australia injury to initial downregulation of ADK, rise in extracellular adenosine,
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br Methods and results ACE is a Canadian
2023-02-25
Methods and results ACE is a Canadian satellite mission [7] that measures atmospheric PMX 205 spectra in the limb geometry using the Sun as a light source (solar occultation). The ACE orbit (74° inclination to the equator, 650 km altitude) concentrates measurements at high latitudes but also prov
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Macrophage polarization is linked to activation of the
2023-02-25
Macrophage polarization is linked to activation of the ligand-dependent transcription factor PPARγ. Recently, Odegaard et al. demonstrated with a macrophage-specific deletion of PPARγ in mice that alternative macrophage activation is impaired [14]. We provided evidence that contact to apoptotic Hepa
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br Autophagy inducers Macroautophagy is often seen
2023-02-25
Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of BI 6015 mg and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing sensitivity of
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