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Autocrine regulations of several adipokines
2023-12-26
Autocrine regulations of several adipokines (e.g., leptin and resistin) on adipocytes have been reported (Karastergiou and Mohamed-Ali, 2010, Ye et al., 2010). Several lines of evidence have shown that apelin influences adipocyte functions, such as, lipolysis and glucose uptake (Dray et al., 2008, Y
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A next series of experiments explored whether cardiac
2023-12-26
A next series of experiments explored whether cardiac Ampkα1 acetylcholine receptors is modified in response to pressure overload imposed by TAC. As a result, 2weeks of TAC treatment significantly increased Ampkα1 protein abundance in cardiac tissue from Ampkα1+/+ mice as compared to sham treated m
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br Funding This work was supported by the National
2023-12-26
Funding This work was supported by the National Natural Science Foundation of China (grant No. 81573664). Thanks to Jing-xian Yang from the Pharmacology Laboratory of Liaoning University of Traditional Chinese Medicine for support with technology and experimental equipment. Disclosure Confl
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Glycosylphosphatidylinositol GPI cell wall anchor synthesis
2023-12-26
Glycosylphosphatidylinositol (GPI) AZD8931 synthesis anchor synthesis pathway is another promising antifungal target. Novel inhibitors of Gwt1 and Mcd4, two enzymes in the GPI anchor pathway were identified by the chemical-genomics-based screening platform CaFT (Candida albicans fitness test) [89].
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Recent studies revealed that certain plant derived compounds
2023-12-26
Recent studies revealed that certain plant-derived compounds can also interfere with AR function. One way of such an interference is by modulating its expression levels. This is the case for the two flavonoids quercetin and luteolin that have been reported to repress the function of AR by inhibiting
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br The role of LOX plays in
2023-12-26
The role of 12/15-LOX plays in autophagy Autophagy is a process by which cellular material is delivered to lysosomal to degrade the damaged organelles and proteins to facilitate nutrient recycling (Towers and Thorburn, 2016). There has been characterized three types of autophagy-macroautophagy, m
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Recently two distinct small molecule inhibitors of PHGDH wer
2023-12-26
Recently, two distinct small-molecule inhibitors of PHGDH were identified using high-throughput screens, both of which inhibit de novo serine biosynthesis and show selective toxicity to cancer topirimate with high SSP flux [50,51]. The inhibitor NCT-503, which has an IC50 of 2.5μM, reduces the grow
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The functional observations from the present study are
2023-12-25
The functional observations from the present study are based on neoplastic hsp90 inhibitors (HSY), and comparative expressions between normal salivary and pleomorphic adenoma tissues. However, there is a paucity of information on AhR expression and function in normal salivary gland, not neoplastic,
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In addition to the above
2023-12-25
In addition to the above-mentioned synaptic mechanisms, the serotonergic system also has a critical role in the antidepressant effects of mGlu2/3 receptor antagonists. Indeed, we previously reported that mGlu2/3 receptor antagonists increased the firing rate of serotonin neurons in the dorsal raphe
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The authors thank Dr J Aoki University of
2023-12-25
The authors thank Dr. J. Aoki, University of Tokyo, for kindly providing 5E5-ATX antibody. This work was supported by a grant from the Deutsche Forschungsgemeinschaft to A.E.K. (KR4391/1-1), research grants “Primary sclerosing cholangitis” from the Deutsche Crohn-Colitis-Vereinigung and the Norwegia
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Many reports have well documented that signaling pathways
2023-12-25
Many reports have well documented that signaling pathways play a pivotal role in controlling longevity. The most studied of these pathways is the IGF-1 pathway [11,12]. A disruption of this pathway has been found to extend longevity in different groups of species starting from Caenorhabditis elegans
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In addition to drawing attention to Ser of
2023-12-25
In addition to drawing attention to Ser454 of ACL as a phosphosite that is regulated by both BDK and PPM1K, our phospho-proteomics screen identified several additional sites in other proteins. For example, Ser25, Ser29, and Ser79 of the lipogenic enzyme acetyl-coA carboxylase 1 (ACC1) were found to
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AZD8931 ARG I is one of the
2023-12-25
ARG I is one of the most important mammalian enzymes responsible for nitrogen metabolism since it comprises the main route for the elimination of excess nitrogen resulting from amino AZD8931 and nucleotide metabolism [18]. ARG I deficiency leads to hyperargininemia, characterized by progressive neu
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Although apelin g kg shows negative early and
2023-12-25
Although apelin 60μg/kg shows negative (early) and positive (late) inotropic effects, since ERK1/2 phosphorylation starts at the min 5 of administration [6], ERK1/2 phosphorylation mediate positive inotropic effects of apelin 60μg/kg. After the simultaneous inhibition of KOR and APJ the phosphoryla
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br Material and methods br Results br Discussion Didox was
2023-12-25
Material and methods Results Discussion Didox was originally created asa cytostatic drug to inhibit cancer cell proliferation by antagonizing RNR [11]. When used to target highly proliferative cells, Didox has extensive activity in vitro and in vivo. It has also been employed in clinical st
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