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Another important question concerns the mechanism by
2024-01-25
Another important question concerns the mechanism by which a polyubiquitinated substrate is released from the Cdc48 complex and passed on to downstream components, such as the proteasome. There are at least three proposed models. In the first, a ubiquitinated substrate is transferred by ubiquitin-bi
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Another important question concerns the mechanism by
2024-01-25
Another important question concerns the mechanism by which a polyubiquitinated substrate is released from the Cdc48 complex and passed on to downstream components, such as the proteasome. There are at least three proposed models. In the first, a ubiquitinated substrate is transferred by ubiquitin-bi
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In considering the roles of these enzymes
2024-01-25
In considering the roles of these enzymes in normal physiology, given the importance of GLUT4-dependent glucose uptake and glucose-dependent fatty GSK2578215A synthesis for systemic metabolic homeostasis (Herman and Kahn, 2006, Herman et al., 2012), deletion of Acly in adipocytes results in a surpr
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br Materials and methods br Results br Discussion Many studi
2024-01-25
Materials and methods Results Discussion Many studies investigate the role of 12/15-LOX in cancer cell,23, 24, 25 however we here first found that host 12/15-LOX also plays an important role in metastasis progression. We have demonstrated that 12(S)-HETE increased melanoma cell adhesion to
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The current literature clearly states that there
2024-01-25
The current literature clearly states that there are no widely adopted standardized methods to determine the total antioxidant capacity of foods or biological samples. One should consider the antioxidant reaction mechanism in system to determine the most appropriate methods for the measurement. It h
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On the other hand oxygen concentration in tumor tissue
2024-01-25
On the other hand, oxygen concentration in tumor tissue also depends on its consumption rate by tumor cells, which decrease will also lead to alleviation of hypoxia. This fact is not taken into account in the majority of studies on the topic, although it is well-known that antiangiogenic therapy doe
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APPL is highly expressed in pancreatic
2024-01-25
APPL1 is highly expressed in pancreatic β cells, but its levels are significantly decreased in several mouse models of obesity and diabetes, including HFD-induced obese mice and db/db mice [6], [73], suggesting that the dysregulation of APPL1 may be associated with malfunction of the pancreas in obe
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Adenosine can modulate neutrophil bactericidal functions
2024-01-25
Adenosine can modulate neutrophil bactericidal functions. A dual regulatory effect has been reported for adenosine on phagocytosis. Indeed, the activation of A1 receptors augments this process, while the stimulation of A2A receptors was found to reduce the phagocytic activity of neutrophils [89]. In
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br Acknowledgment br Introduction Vascular
2024-01-25
Acknowledgment Introduction Vascular smooth muscle cells (VSMC) exhibit the capacity to switch between a differentiated (contractile) and a dedifferentiated (synthetic) phenotype [1]. Synthetic VSMC express a lower amount of contractile proteins such as Smooth muscle 22α (sm22α) and α-Smooth m
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br Dihydrotestosterone in adult fish and frogs
2024-01-24
Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance
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br Research perspective In vitro and
2024-01-24
Research perspective In vitro and in vivo studies have demonstrated that increased LPA/ATX signaling contributes to cancer initiation and progression. Recent findings on the role of non-tumoral ATX in cancer progression and metastasis highlighted a new functional contribution for the microenviron
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Recent studies have indicated that V ATPase
2024-01-24
Recent studies have indicated that V-ATPase activity negatively regulates vacuolar fusion in vivo[17]. Since we have demonstrated that the pah1Δ Dapoxetine HCl have a more acidic vacuolar pH than the WT cells, and the genes involved in the pump activity are upregulated compared to WT, the pah1Δ cel
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According to the diversity in
2024-01-24
According to the DHAP in molecular skeletons, aromatase inhibitors can be categorized into two types: steroidal and non-steroidal blockers [6]. Steroidal AI (e.g., exemestane in Fig. 1) derived from the substrate androstenedione interacts with aromatase through chemical actions, resulting in an irre
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br Materials and methods br Results br Discussion Pulmonary
2024-01-24
Materials and methods Results Discussion Pulmonary fibrosis is a progressive and chronic lung disease and its typical features include lactone mg proliferation, epithelial injury, chronic interstitial inflammation, increased extracellular matrix (ECM) production, and collapse of alveoli, a
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br Application of bamboo in the food and pharmaceutical indu
2024-01-24
Application of bamboo in the food and pharmaceutical industry For decades, the application of antioxidants in the food and pharmaceutical industry has been widespread. In the past, antioxidants were previously used to control oxidation and retard spoilage but today, many are used because of putat
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